Evidence-led answers, one question at a time.

Science

How do GLP-1 medications actually work?

The mechanism in plain English — appetite, blood sugar, and why it drives weight loss.

Body composition

How to protect your muscle on a GLP-1

The protein and training approach that keeps weight loss from becoming muscle loss.

Safety & eligibility

Is microdosing GLP-1 effective for metabolic health?

"Microdosing" GLP-1 receptor agonists — meaning the deliberate use of doses well below the standard therapeutic range — is not a formally st

Safety & eligibility

Who should not take a GLP-1 medication?

GLP-1 receptor agonists are prescription-only medicines and are not suitable for everyone. Key groups who are generally advised against usin

Safety & eligibility

What are the serious or irreversible risks of GLP-1 medications?

GLP-1 receptor agonists carry several recognised serious risks, including pancreatitis, gallbladder disease, a precautionary warning regardi

Safety & eligibility

What would make a doctor refuse to prescribe a GLP-1?

A doctor may decline to prescribe a GLP-1 receptor agonist if a patient has certain medical contraindications, does not meet prescribing cri

Getting started

What are common GLP-1 side effects and how do you manage them?

The most frequently reported side effects of GLP-1 receptor agonists are gastrointestinal — nausea, vomiting, diarrhoea, constipation, and a

Getting started

What should you eat while on GLP-1 medication?

While taking a GLP-1 receptor agonist, most clinical guidance emphasises a diet built around lean protein, non-starchy vegetables, healthy f

Education

Semaglutide vs tirzepatide: What is the difference?

Semaglutide and tirzepatide are both injectable prescription medications used in the management of type 2 diabetes and, in certain approved

Getting started

How do you reduce nausea on semaglutide?

Nausea is the most commonly reported side effect of semaglutide, typically occurring when treatment begins or when a dose is increased. Evid

Optimisation

Natural ways to support GLP-1 hormone levels

Several lifestyle and dietary strategies may help support the body's natural production of glucagon-like peptide-1 (GLP-1), a gut hormone in

Optimisation

Best supplements to take alongside a GLP-1 medication

When taking a GLP-1 receptor agonist, reduced caloric intake can increase the risk of certain nutritional shortfalls, making targeted supple

Optimisation

How much protein should you eat on a GLP-1 to preserve muscle?

Most obesity-medicine specialists and dietitians recommend that adults losing weight while taking a GLP-1 receptor agonist aim for approxima

Optimisation

How do you optimise metabolic health for longevity?

Optimising metabolic health for longevity involves sustaining healthy blood glucose regulation, insulin sensitivity, lipid profiles, blood p

Optimisation

How should you train and exercise while on a GLP-1?

When using a GLP-1 receptor agonist, exercise remains one of the most important factors for achieving positive health outcomes — particularl

Optimisation

What blood markers should you track on a weight-loss journey?

Tracking blood markers during weight loss helps you monitor metabolic health beyond the scale. Key markers to discuss with your doctor inclu

Staying the course

How do you maintain weight loss after stopping a GLP-1?

Maintaining weight loss after discontinuing a GLP-1 receptor agonist requires a structured, long-term approach combining sustained dietary c